Reduced sperm function on sulfasalazine

The agent is currently approved in the US, however, only in patients who have failed TNF antagonists. The dose may be reduced to 10mg daily if not tolerated at the 20 mg dose. The medication is administered over a period of approximately 30 minutes to one hour. TB screening is recommended. Occasionally, mild cytopenias are seen.
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Rheumatoid Arthritis Treatment

Like gold it is a relatively toxic drug that has limited utility due to issues of tolerability and efficacy that is not as robust as other currently available agents. Sulfasalazine is a pregnancy category B drug. Side effects listed as postmarketing reports were reported during postmarketing experience with the use of products containing or metabolized to mesalamine. Baillie J "Sulfasalazine and pulmonary infiltrates. Obesity, diabetes and history of hepatitis B or C are factors that have been suggested but not confirmed to increase methotrexate hepatotoxicity liver injury. Antibiotics for Unexplained Infertility?
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Sulfasalazine - an overview | ScienceDirect Topics

However, many rheumatology practices are following that practice. Though sulfasalazine may cause increases in liver function tests, it is generally considered a preferable agent to methotrexate in patients with liver disease or in patients who have hepatitis B or C. The optimal time for readministration is not yet clear. Yellow discoloration of skin and body fluids [ Ref ]. Respiratory infections including pneumonia were more common in clinical trials in patients with underlying COPD, thus extreme caution is suggested in this population.
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Interestingly, in contrast to UC, the active metabolite in RA patients is sulfapyridine, although the exact mechanism of action has not been clearly identified. Sulfasalazine appears in breast milk in significant concentrations. Gift one of these products and they'll thank you forever! The teratogenic potential of Infliximab is also unknown. Polycythemia vera PV is a rare bone marrow disorder in which the body makes too many red blood cells.
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